Title : Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.

Pub. Date : 1997 Nov 17

PMID : 9362518






1 Functional Relationships(s)
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1 While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38. acetyl-aspartyl-glutamyl-valyl-aspartal mitogen-activated protein kinase 14 Homo sapiens