Title : Danazol induced cholestasis: pathogenetic hypothesis.

Pub. Date : 1997 Sep

PMID : 9360432






2 Functional Relationships(s)
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1 Our hypothesis is based on the fact that danazol is administered in the treatment of pulmonary emphysema because it stimulates synthesis of alpha-1 antitrypsin and that other estrogen glucuro-conjugated metabolites are P-glycoprotein substrates. Danazol serpin family A member 1 Homo sapiens
2 We believe that genetic alterations of alpha-1 antitrypsin and P-glycoprotein, either alone or in association with known pathogenetic mechanisms, may explain the onset of danazol induced cholestasis and justify the difference in its varying duration and intensity. Danazol serpin family A member 1 Homo sapiens