Title : Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.

Pub. Date : 1997 Nov 15

PMID : 9359870






1 Functional Relationships(s)
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1 We demonstrate that mt-TK does not show an absolute enantioselectivity, being able to recognize, although with lower efficiency, the L-enantiomers of thymidine, deoxycytidine and modified deoxyuridines, such as (E)-5-(2-bromovinyl)-2"-deoxyuridine and 5-iodo-2"-deoxyuridine. Deoxycytidine thymidine kinase 2 Homo sapiens