Title : Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation.

Pub. Date : 1997 Oct

PMID : 9357820






2 Functional Relationships(s)
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1 H2O2 treatment led to increases in c-fos and c-jun mRNA levels, Jun nuclear kinase activity, and AP-1 DNA binding. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Cells expressing antisense c-jun had decreased levels of AP-1 activation and significantly increased survival after H2O2 exposure. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens