Title : Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha.

Pub. Date : 1997 Oct

PMID : 9355959






6 Functional Relationships(s)
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1 Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha. Quinolinic Acid tumor necrosis factor Homo sapiens
2 We, therefore, sought to determine the role of tumor necrosis factor-alpha (TNF-alpha) and IFN-alpha in the production of QUIN. Quinolinic Acid tumor necrosis factor Homo sapiens
3 We, therefore, sought to determine the role of tumor necrosis factor-alpha (TNF-alpha) and IFN-alpha in the production of QUIN. Quinolinic Acid tumor necrosis factor Homo sapiens
4 Results at 72 h showed significant increases in QUIN production in the cells stimulated with IFN-gamma (10297 +/- 170 nmol/L) and also in those stimulated with IFN-alpha (3600 +/- 113 nmol/L), whereas TNF-alpha-stimulated macrophages produced low levels of QUIN (1108 +/- 23 nmol/L). Quinolinic Acid tumor necrosis factor Homo sapiens
5 Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively). Quinolinic Acid tumor necrosis factor Homo sapiens
6 Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively). Quinolinic Acid tumor necrosis factor Homo sapiens