Pub. Date : 1997 Nov 1
PMID : 9354463
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. | betulinic acid | caspase 8 | Homo sapiens |
| 2 | BA-induced apoptosis was independent of CD95-ligand/receptor interaction and accumulation of wild-type p53 protein, but it critically depended on activation of caspases (interleukin 1beta-converting enzyme/Ced-3-like proteases). | betulinic acid | caspase 8 | Homo sapiens |
| 3 | The broad-spectrum peptide inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, which blocked cleavage of FLICE and PARP, also completely abrogated BA-triggered apoptosis. | betulinic acid | caspase 8 | Homo sapiens |
| 4 | This suggested that mitochondrial alterations were involved in BA-induced activation of caspases. | betulinic acid | caspase 8 | Homo sapiens |