Title : Effects of antimitotic agents on secretion and detergent extractibility of adrenal nicotinic acetylcholine receptors.

Pub. Date : 1997 Oct

PMID : 9353587






1 Functional Relationships(s)
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1 Functional studies demonstrated that vincristine, tubulozole, podophyllotoxin, and demecolcine inhibited nAChR-stimulated catecholamine release noncompetitively and in a concentration-dependent manner, with IC50 values of 3 (1-10), 5 (2-10), 8 (4-15), and 19 (9-39) microM, respectively. Catecholamines cholinergic receptor nicotinic alpha 4 subunit Homo sapiens