Title : Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.

Pub. Date : 1997 Nov

PMID : 9353419






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Direct action of hymenialdisine on IL-1-induced NFkappaB activation was demonstrated by a significant reduction (approximately 80%) in NFkappaB binding to the classical kappaB consensus motif (as assessed by electrophoretic mobility shift assay) and inhibition of stimulated p65 migration from the cytosol of treated cells (as assessed by Western analysis). hymenialdisine RELA proto-oncogene, NF-kB subunit Homo sapiens