Title : An orally active selenium-based antihypertensive agent with restricted CNS permeability.

Pub. Date : 1997 Nov

PMID : 9353359






1 Functional Relationships(s)
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1 As a consequence of the redox chemistry of the selenium moiety, phenylaminoalkyl selenides possess the remarkable characteristic of propagating a cycle of turnover-dependent local depletion of reduced ascorbate when processed by the key enzyme of catecholamine metabolism, dopamine-beta-monooxygenase. Catecholamines dopamine beta-hydroxylase Rattus norvegicus