Pub. Date : 1997 Oct
PMID : 9351366
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated the contribution of apoE to cholesterol efflux into plasmas of normal, apoA-I-, and apoE-deficient mice, which were fed with chow- and cholesterol-rich diets. | Cholesterol | apolipoprotein E | Mus musculus |
| 2 | When apoA-I- and apoE-deficient mice received both chow- and fat-rich diets, their plasmas released significantly less 3H-cholesterol from radiolabeled fibroblasts than did plasma of normal mice. | Cholesterol | apolipoprotein E | Mus musculus |
| 3 | Removal of apoE from plasmas of normal and apoA-I-deficient mice by anti-apoE immunoaffinity chromatography decreased their cholesterol efflux capacities (per 1 minute/per 1 hour) by 26%/40% (P = 0.0092/0.0007) and 30%/26% (P = 0.0092/0.0003), respectively. | Cholesterol | apolipoprotein E | Mus musculus |
| 4 | Removal of apoE from plasmas of normal and apoA-I-deficient mice by anti-apoE immunoaffinity chromatography decreased their cholesterol efflux capacities (per 1 minute/per 1 hour) by 26%/40% (P = 0.0092/0.0007) and 30%/26% (P = 0.0092/0.0003), respectively. | Cholesterol | apolipoprotein E | Mus musculus |
| 5 | Incubation of fibroblasts with apoE-deficient plasma caused net influx of cholesterol. | Cholesterol | apolipoprotein E | Mus musculus |
| 6 | Some of the differences between cholesterol efflux into normal and apoE-deficient plasmas were attributable to the failure of apoE-deficient plasmas to take up cell-derived 3H-cholesterol into gamma-LpE. | Cholesterol | apolipoprotein E | Mus musculus |
| 7 | Compared with normal plasma, both apoA-I-deficient and apoE-deficient plasmas were significantly decreased in their activity to esterify cell-derived 3H-cholesterol. | Cholesterol | apolipoprotein E | Mus musculus |
| 8 | Anti-apoE chromatography decreased significantly cholesterol esterification in normal plasma and apoA-I-deficient plasma but not in apoE-deficient plasma. | Cholesterol | apolipoprotein E | Mus musculus |
| 9 | Taken together, the data provide evidence that apoE is an important contributor to reverse cholesterol transport, partially because of initial uptake of cell-derived cholesterol by gamma-LpE and partially because of the contribution of apoE-containing lipoproteins to esterification of cholesterol in plasma. | Cholesterol | apolipoprotein E | Mus musculus |
| 10 | Taken together, the data provide evidence that apoE is an important contributor to reverse cholesterol transport, partially because of initial uptake of cell-derived cholesterol by gamma-LpE and partially because of the contribution of apoE-containing lipoproteins to esterification of cholesterol in plasma. | Cholesterol | apolipoprotein E | Mus musculus |
| 11 | Taken together, the data provide evidence that apoE is an important contributor to reverse cholesterol transport, partially because of initial uptake of cell-derived cholesterol by gamma-LpE and partially because of the contribution of apoE-containing lipoproteins to esterification of cholesterol in plasma. | Cholesterol | apolipoprotein E | Mus musculus |