Pub. Date : 1997 Nov
PMID : 9348211
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vanadate, but not insulin, inhibits insulin receptor gene expression in rat hepatoma cells. | Vanadates | insulin receptor | Rattus norvegicus |
| 2 | Insulin and vanadate treatments have recently been shown to reverse the overexpression of the hepatic insulin receptor (IR) gene in streptozotocin-induced diabetic rats. | Vanadates | insulin receptor | Rattus norvegicus |
| 3 | Insulin and vanadate treatments have recently been shown to reverse the overexpression of the hepatic insulin receptor (IR) gene in streptozotocin-induced diabetic rats. | Vanadates | insulin receptor | Rattus norvegicus |
| 4 | To better understand the mechanisms underlying these effects, the abilities of insulin and vanadate to affect IR gene expression have been comparatively examined in Fao hepatoma cells, an insulin-responsive cell line. | Vanadates | insulin receptor | Rattus norvegicus |
| 5 | Exposure of Fao cells to insulin (1 microM) or vanadate (500 microM) for 24 h led to a 2-fold decrease in IR number in total cellular membranes. | Vanadates | insulin receptor | Rattus norvegicus |
| 6 | In contrast, vanadate treatment caused a time- and dose-dependent decrease in IR mRNA level, which was maximal (4-fold change) after a 24-h exposure to 500 microM vanadate and was fully reversible. | Vanadates | insulin receptor | Rattus norvegicus |
| 7 | In contrast, vanadate treatment caused a time- and dose-dependent decrease in IR mRNA level, which was maximal (4-fold change) after a 24-h exposure to 500 microM vanadate and was fully reversible. | Vanadates | insulin receptor | Rattus norvegicus |
| 8 | Vanadate treatment did not modify mRNA half-life (3.5 h) in 5, 6 dichlorobenzimidazole riboside-treated cells but decreased by 4-fold the transcriptional activity of the IR gene. | Vanadates | insulin receptor | Rattus norvegicus |
| 9 | These data show for the first time that, although both insulin and vanadate decrease total cellular IR number in Fao cells, only vanadate decreases IR mRNA level. | Vanadates | insulin receptor | Rattus norvegicus |
| 10 | These data show for the first time that, although both insulin and vanadate decrease total cellular IR number in Fao cells, only vanadate decreases IR mRNA level. | Vanadates | insulin receptor | Rattus norvegicus |