Pub. Date : 1997 Oct
PMID : 9347086
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPS and DB-cAMP each increased iNOS mRNA and protein in AM and RNI in the BAL fluid and ex vivo incubates of AM. | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | However, the peak of the increase of iNOS mRNA occurred at 2 hr for DB-cAMP and 4 to 6 hr for LPS. | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | In contrast, pretreatment of rats with ETOH did not affect DB-cAMP-mediated increases of iNOS mRNA in AM at any time but suppressed the amount of iNOS protein and RNI produced in DB-cAMP-stimulated AM. | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | Also, since ETOH inhibited DB-cAMP-mediated increases in iNOS protein without affecting iNOS mRNA ETOH also acts at a post-transcriptional or translational site to inhibit iNOS protein in rat AM in vivo. | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |