Title : New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.

Pub. Date : 1997 Oct 28

PMID : 9341205






1 Functional Relationships(s)
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1 Highly effective thrombin inhibitors have been obtained by preparing boronic acid analogues of m-cyano-substituted phenylalanine and its incorporation into peptides. Boronic Acids coagulation factor II, thrombin Homo sapiens