Title : Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.

Pub. Date : 1997 Oct 15

PMID : 9329968






5 Functional Relationships(s)
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1 Next, we evaluated the effect of cyclosporine (CsA) on iNOS expression and allograft arteriosclerosis. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
2 Next, we evaluated the effect of cyclosporine (CsA) on iNOS expression and allograft arteriosclerosis. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
3 CsA (10 mg/kg/d) suppressed the expression of iNOS in response to balloon-induced aortic injury. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
4 Similarly, CsA inhibited iNOS expression in the aortic allografts, associated with a 65% increase in intimal thickening. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
5 Transduction with iNOS using an adenoviral vector suppressed completely the development of allograft arteriosclerosis in both untreated recipients and recipients treated with CsA. Cyclosporine nitric oxide synthase 2 Rattus norvegicus