Title : In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s.

Pub. Date : 1997 Oct

PMID : 9321523






1 Functional Relationships(s)
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1 The results suggested that the in vivo inhibitory effects of SV on the metabolism of CYP3A substrates likely would be less than those of ketoconazole and itraconazole at their respective therapeutic concentrations. Simvastatin cytochrome P450 family 3 subfamily A member 4 Homo sapiens