Pub. Date : 1997 Sep
PMID : 9316423
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor of polyamine synthesis, for 4 or 6 days not only almost completely depleted total (whole) cellular and nuclear polyamines but also significantly decreased expression of the protooncogenes c-myc and c-jun in IEC-6 cells. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Rattus norvegicus |
| 2 | Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor of polyamine synthesis, for 4 or 6 days not only almost completely depleted total (whole) cellular and nuclear polyamines but also significantly decreased expression of the protooncogenes c-myc and c-jun in IEC-6 cells. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Rattus norvegicus |
| 3 | Using nuclear run-on transcription assay, we demonstrated that the basal rate of transcription of c-myc was decreased by 55% at 4 days and by 60% at 6 days in the DFMO-treated cells. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Rattus norvegicus |
| 4 | Furthermore, direct administration of spermidine to isolated nuclei from polyamine-deficient (caused by DFMO) cells resulted in a 2- to 2.5-fold increase in c-myc and c-jun transcription. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Rattus norvegicus |