Title : Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.

Pub. Date : 1997 Sep

PMID : 9314612






1 Functional Relationships(s)
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1 Felbamate has been shown in vitro to inhibit CYP2C19, which would account for its effect on phenytoin clearance, and it had been postulated that this could be the mechanism underlying the reduced clearance of phenobarbital by felbamate. Phenobarbital cytochrome P450 family 2 subfamily C member 19 Homo sapiens