Title : Efficacy of danazol in a patient with congenital protein-S deficiency: paradoxical evidence for decreased platelet activation with increased thrombin generation.

Pub. Date : 1997 Sep 1

PMID : 9306621






4 Functional Relationships(s)
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1 Efficacy of danazol in a patient with congenital protein-S deficiency: paradoxical evidence for decreased platelet activation with increased thrombin generation. Danazol coagulation factor II, thrombin Homo sapiens
2 Both Prothrombin Fragment 1.2 and thrombin-antithrombin complexes were elevated post danazol therapy indicating continued clearance of generated thrombin. Danazol coagulation factor II, thrombin Homo sapiens
3 Both Prothrombin Fragment 1.2 and thrombin-antithrombin complexes were elevated post danazol therapy indicating continued clearance of generated thrombin. Danazol coagulation factor II, thrombin Homo sapiens
4 These data suggest that the protective effect provided by danazol in this patient with hereditary PS deficiency, may in large part be due to suppression of platelet activation by thrombin inhibition than simply through elevation of PS. Danazol coagulation factor II, thrombin Homo sapiens