Title : Differential effects of phorbol ester on signaling and gene expression in human leukemia cells.

Pub. Date : 1997 Jul

PMID : 9301678






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Expression of the c-myc gene was down-regulated and c-jun and c-fms transcripts increased following exposure to 5-500 nM TPA. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 In contrast, exposure to 0.5 nM TPA decreased c-myc expression and increased c-jun transcripts only transiently between 4 and 8 h while little if any effect was detectable on c-fms mRNA expression and subsequent differentiation. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens