Pub. Date : 1997 May
PMID : 9300530
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated the role of internalization motifs located in the cytosolic region of CD3 gamma in the internalization of TCR complexes induced by enterotoxin superantigens, anti-TCR mAbs or phorbol esters. | Phorbol Esters | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 2 | We found that serine126 and the di-leucine motif (Leu131-Leu132) are required for phorbol-ester-induced TCR downregulation, but they are not necessary for enterotoxin superantigen or antibody-induced TCR downregulation. | Phorbol Esters | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 3 | We found that serine126 and the di-leucine motif (Leu131-Leu132) are required for phorbol-ester-induced TCR downregulation, but they are not necessary for enterotoxin superantigen or antibody-induced TCR downregulation. | Phorbol Esters | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 4 | Confocal microscopy analysis reveals that TCR complexes accumulate in an early endocytic/recycling compartment upon activation of cells with phorbol esters, whereas TCRs internalized upon activation with superantigen or anti-TCR mAbs are routed to lysosomes. | Phorbol Esters | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |