Title : Applications of primary human hepatocytes in the evaluation of pharmacokinetic drug-drug interactions: evaluation of model drugs terfenadine and rifampin.

Pub. Date : 1997 Jul

PMID : 9298257






1 Functional Relationships(s)
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1 To demonstrate that the rifampin-induction of testosterone 6 beta-hydroxylation could be generalized to other CYP3A4 substrates, we evaluated the metabolism of another known substrate of CYP3A4, lidocaine. Lidocaine cytochrome P450 family 3 subfamily A member 4 Homo sapiens