Title : Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis.

Pub. Date : 1997 Aug

PMID : 9295059






3 Functional Relationships(s)
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1 In a subset of 14 breast cancer cases and 32 study controls, the mean PARP enzyme activities (induced by H2O2 or oligonucleotide) were observed to be lower in cancer cases; an age-adjusted odds ratio of 3.40 (95% confidence interval = 0.70-19.54) for the below-median oligonucleotide-induced PARP was suggestive of an association. Hydrogen Peroxide poly(ADP-ribose) polymerase 1 Homo sapiens
2 In a subset of 14 breast cancer cases and 32 study controls, the mean PARP enzyme activities (induced by H2O2 or oligonucleotide) were observed to be lower in cancer cases; an age-adjusted odds ratio of 3.40 (95% confidence interval = 0.70-19.54) for the below-median oligonucleotide-induced PARP was suggestive of an association. Hydrogen Peroxide poly(ADP-ribose) polymerase 1 Homo sapiens
3 In subjects with the AB or BB genotype, the mean H2O2-induced PARP enzyme activity was significantly higher (p = 0.02, adjusted for case-control status and age) compared with that in subjects with the AA genotype. Hydrogen Peroxide poly(ADP-ribose) polymerase 1 Homo sapiens