Title : Oxidation of human insulin-like growth factor I in formulation studies. 3. Factorial experiments of the effects of ferric ions, EDTA, and visible light on methionine oxidation and covalent aggregation in aqueous solution.

Pub. Date : 1997 Sep

PMID : 9294820






5 Functional Relationships(s)
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1 The influence of ferric ions, EDTA, and visible light on the oxidation of methionine and the covalent reducible and nonreducible dimerization in human Insulin-like Growth Factor I (hIGF-I) in aqueous (1 mM) phosphate buffer solution were studied. Ferric enterobactin ion insulin like growth factor 1 Homo sapiens
2 The covalent dimerization of hIGF-I was correlated to visible light and ferric ions. Ferric enterobactin ion insulin like growth factor 1 Homo sapiens
3 The oxidation of methionine 59 in hIGF-I is catalyzed by light and by ferric ions in combination with EDTA. Ferric enterobactin ion insulin like growth factor 1 Homo sapiens
4 The covalent dimerization of hIGF-I is mainly affected by light and by ferric ions. Ferric enterobactin ion insulin like growth factor 1 Homo sapiens
5 EDTA is necessary for ferric ions to be active in the oxidation of methionine in hIGF-I but not for the covalent dimerization. Ferric enterobactin ion insulin like growth factor 1 Homo sapiens