Title : Tyrosine phosphorylation and bradykinin-induced signaling in endothelial cells.

Pub. Date : 1997 Aug 4

PMID : 9293962






3 Functional Relationships(s)
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1 In cultured human endothelial cells, bradykinin induced a rapid increase in the tyrosine phosphorylation of several Triton-soluble proteins. Tyrosine kininogen 1 Homo sapiens
2 Immunoprecipitation of tyrosine-phosphorylated proteins from bradykinin-stimulated cells followed by Western blotting using the respective antibodies facilitated the identification of a 77 kiloDalton (kDa) protein as paxillin, a 130 kDa protein as PLC-gamma1, and a 42/44 kDa doublet as mitogen-activated protein (MAP) kinase. Tyrosine kininogen 1 Homo sapiens
3 The bradykinin-induced tyrosine phosphorylation of PLC-gamma1 was relatively transient and was associated with an increase in intracellular levels of IP3. Tyrosine kininogen 1 Homo sapiens