Title : Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice.

Pub. Date : 1997 Sep

PMID : 9293904






2 Functional Relationships(s)
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1 In the present study we show that MGMT expressing bone marrow (BM) progenitors can be selected for in vivo by BCNU administration. Carmustine O-6-methylguanine-DNA methyltransferase Mus musculus
2 MGMT+ mice treated with multiple doses of BCNU and examined 13 to 17 weeks after transplantation displayed a 2.4-fold increase in the percentage of progenitors with evidence of proviral integration (p < 0.0001). Carmustine O-6-methylguanine-DNA methyltransferase Mus musculus