Title : Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.

Pub. Date : 1997 Sep

PMID : 9292787






4 Functional Relationships(s)
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1 Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells. Quercetin C-C motif chemokine ligand 2 Homo sapiens
2 RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner. Quercetin C-C motif chemokine ligand 2 Homo sapiens
3 H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin. Quercetin C-C motif chemokine ligand 2 Homo sapiens
4 CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B. Quercetin C-C motif chemokine ligand 2 Homo sapiens