Title : mdm 2 mRNA expression is associated with survival in ovarian cancer.

Pub. Date : 1997 Aug 22

PMID : 9291435






3 Functional Relationships(s)
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1 Our results suggest that mdm-2, which is known to disrupt p53 function, sensitizes ovarian-cancer cells to cisplatin/cyclophosphamide, possibly by inhibition of p53-mediated G1 cell-cycle arrest and p53-stimulated nucleotide-excision repair. Cyclophosphamide tumor protein p53 Homo sapiens
2 Our results suggest that mdm-2, which is known to disrupt p53 function, sensitizes ovarian-cancer cells to cisplatin/cyclophosphamide, possibly by inhibition of p53-mediated G1 cell-cycle arrest and p53-stimulated nucleotide-excision repair. Cyclophosphamide tumor protein p53 Homo sapiens
3 Our results suggest that mdm-2, which is known to disrupt p53 function, sensitizes ovarian-cancer cells to cisplatin/cyclophosphamide, possibly by inhibition of p53-mediated G1 cell-cycle arrest and p53-stimulated nucleotide-excision repair. Cyclophosphamide tumor protein p53 Homo sapiens