Pub. Date : 1997 Sep
PMID : 9283792
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glibenclamide, but not acarbose, increases leptin concentrations parallel to changes in insulin in subjects with NIDDM. | Glyburide | insulin | Homo sapiens |
| 2 | OBJECTIVE: To hypothesize if glibenclamide, which increases insulin levels, also increases leptin concentrations. | Glyburide | insulin | Homo sapiens |
| 3 | Differing effects can be expected, since glibenclamide acts via stimulation of insulin secretion, whereas acarbose inhibits alpha-glucosidases of the small intestine and has no direct effect on insulin levels. | Glyburide | insulin | Homo sapiens |
| 4 | CONCLUSIONS: Glibenclamide increases circadian leptin and insulin concentrations, whereas acarbose does not. | Glyburide | insulin | Homo sapiens |