Title : Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells.

Pub. Date : 1997 Aug

PMID : 9283689






2 Functional Relationships(s)
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1 Net secretion of ciprofloxacin was partially inhibited by 100 microM verapamil, whilst net secretion of the P-glycoprotein substrate vinblastine was totally abolished under these conditions. Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens
2 Ciprofloxacin secretion was unaltered after preincubation of cells with two anti-P-glycoprotein antibodies (UIC2 and MRK16), which both significantly reduced secretory vinblastine flux (measured in the same cell batch). Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens