Title : The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells.

Pub. Date : 1997 Sep

PMID : 9282941






3 Functional Relationships(s)
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1 The amyloid beta-protein of Alzheimer"s disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. Calcium acetylcholinesterase (Cartwright blood group) Homo sapiens
2 To examine the possibility that the increase in AChE expression was mediated by an influx of calcium through voltage-dependent calcium channels (VDCCs), drugs acting on VDCCs were tested for their effects. Calcium acetylcholinesterase (Cartwright blood group) Homo sapiens
3 The results suggest that the increase in AChE expression around amyloid plaques could be due to a disturbance in calcium homeostasis involving the opening of L-type VDCCs. Calcium acetylcholinesterase (Cartwright blood group) Homo sapiens