Title : Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.

Pub. Date : 1997 Sep 1

PMID : 9276732






2 Functional Relationships(s)
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1 This alteration in eicosanoid metabolism was associated with induction of cyclooxygenase (Cox)-2 and thromboxane synthase, but not Cox-1. Eicosanoids mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Unlike results seen in other systems, the upregulation of Cox-2 and the subsequent release of eicosanoids by endothelial cells was not directly induced by complement but rather required production of IL-1alpha, which acted on endothelial cells as an autocrine factor. Eicosanoids mitochondrially encoded cytochrome c oxidase II Homo sapiens