Title : Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein.

Pub. Date : 1997 Sep

PMID : 9275063






4 Functional Relationships(s)
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1 Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein. Steroids kallikrein related peptidase 3 Homo sapiens
2 We have compared the steroid regulation of human genes encoding prostatic acid phosphatase (hPAP), prostate-specific antigen (hPSA), and prostate-specific glandular kallikrein (hK2) at the level of transcription. Steroids kallikrein related peptidase 3 Homo sapiens
3 Glucocorticoid was the most powerful activator of the hPSA construct at 10-nM steroid concentrations. Steroids kallikrein related peptidase 3 Homo sapiens
4 The results indicate that the steroid response elements in the proximal promoters of hPSA and hK2 genes are not androgen specific, offering the molecular basis for the expression of these genes outside the prostate in tissues containing steroid receptors. Steroids kallikrein related peptidase 3 Homo sapiens