Title : Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors.

Pub. Date : 1997 Aug

PMID : 9271348






1 Functional Relationships(s)
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1 Mutations of three highly conserved tryptophans (W200A, W336A, and W367A) proposed to reside near the binding pocket markedly reduced agonist affinity and efficacy at 5-HT2A receptors. Tryptophan 5-hydroxytryptamine receptor 2A Homo sapiens