Title : Role of protein-phospholipid interactions in the activation of ARF1 by the guanine nucleotide exchange factor Arno.

Pub. Date : 1997 Aug 29

PMID : 9268368






3 Functional Relationships(s)
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1 Binding of the PH domain to phosphatidylinositol 4,5-bisphosphate (PIP2) greatly enhances Arno-mediated activation of myristoylated ARF1. Phosphatidylinositol 4,5-Diphosphate ADP ribosylation factor 1 Homo sapiens
2 Binding of the PH domain to phosphatidylinositol 4,5-bisphosphate (PIP2) greatly enhances Arno-mediated activation of myristoylated ARF1. Phosphatidylinositol 4,5-Diphosphate ADP ribosylation factor 1 Homo sapiens
3 We conclude that efficient activation of full-length ARF1 by Arno requires a membrane surface and two distinct protein-phospholipid interactions: one between the PH domain of Arno and PIP2, and the other between amino-terminal cationic residues of ARF1 and anionic phospholipids. Phosphatidylinositol 4,5-Diphosphate ADP ribosylation factor 1 Homo sapiens