Title : Bacterial endotoxin inhibits LHRH secretion following the increased release of hypothalamic GABA levels. Different effects on amino acid neurotransmitter release.

Pub. Date : 1996 Nov-Dec

PMID : 9266545






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Bacterial endotoxin inhibits LHRH secretion following the increased release of hypothalamic GABA levels. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
2 Then, knowing that gamma-aminobutyric acid (GABA) mediates other neurotransmitter effects in the central nervous system, the possibility arises that this amino acid might mediate the effect of LPS on LHRH release by modifying amino acid neurotransmitter release at the hypothalamic level. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
3 Then, knowing that gamma-aminobutyric acid (GABA) mediates other neurotransmitter effects in the central nervous system, the possibility arises that this amino acid might mediate the effect of LPS on LHRH release by modifying amino acid neurotransmitter release at the hypothalamic level. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
4 The GABA antagonists blocked and reversed the LPS effect on LHRH secretion. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
5 These observations indicate that there is an increase in GABA release that becomes significant at the same time when LHRH release is decreased. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus