Title : Prostacyclin receptor desensitization is a reversible phenomenon in human platelets.

Pub. Date : 1997 Aug 5

PMID : 9264479






1 Functional Relationships(s)
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1 BACKGROUND: Long-term exposure of platelets to endogenous or exogenous prostacyclin or its analogues might result in desensitization of the platelet prostacyclin receptor in vitro and in vivo accompanied by a loss in receptor density on the platelet surface and a reduced sensitivity toward the inhibitory effects of prostacyclins. Epoprostenol prostaglandin I2 receptor Homo sapiens