Pub. Date : 1997 Jun 1
PMID : 9264313
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Microsomes prepared from different human liver samples were compared for their abilities to metabolize fentanyl, sufentanil and alfentanil, and it was found that disappearance of the three substrates was well correlated with immunoreactive CYP3A4 contents but not with other CYPs, including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6 and CYP2E1. | Fentanyl | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Specific known inhibitors of CYP enzymes gave similar results, whereas the use of recombinant human CYP enzymes expressed in yeast provided information about the possible involvement of other CYPs than CYP3A4 in the biotransformation of fentanyl and sufentanil. | Fentanyl | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The possible in vivo interaction of fentanyl and sufentanil with other drugs catalyzed by CYP3A4 is also discussed. | Fentanyl | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |