Pub. Date : 1997 Aug
PMID : 9262374
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inducible nitric oxide synthase (iNOS) mRNA is up-regulated in vivo by dibutyryl-cAMP (db-cAMP), the purine-2y receptor agonist 2-methylthio-ATP and Escherichia coli endotoxin lipopolysaccharide (LPS). | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | Inducible nitric oxide synthase (iNOS) mRNA is up-regulated in vivo by dibutyryl-cAMP (db-cAMP), the purine-2y receptor agonist 2-methylthio-ATP and Escherichia coli endotoxin lipopolysaccharide (LPS). | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | Their effects on db-cAMP- and 2-methylthio-ATP-stimulated iNOS mRNA remain undefined. | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | Thus, two distinct pathways exist for induction of iNOS mRNA in rat AM in vivo: an NF-kappaB pathway for LPS and cytokines inhibitable by ethanol and diethyldithiocarbamate and an NF-kappaB-independent pathway, refractory to inhibition by ethanol and diethyldithiocarbamate for db-cAMP and 2-mes-ATP. | Bucladesine | nitric oxide synthase 2 | Rattus norvegicus |