Pub. Date : 1997 Aug 22
PMID : 9261121
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | To estimate relative turnovers for pumping of the drug vinblastine and ATP hydrolysis, we began by measuring the number of P-glycoprotein molecules on the surface of murine NIH3T3 cells expressing the human MDR1 gene. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Initial uptake rates of vinblastine +/- verapamil measure the ability of P-glycoprotein to extract vinblastine from the plasma membrane before it enters the cell. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Initial uptake rates of vinblastine +/- verapamil measure the ability of P-glycoprotein to extract vinblastine from the plasma membrane before it enters the cell. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The vinblastine-stimulated ATPase activity of P-glycoprotein has a turnover number of 3.5 s-1 at 37 degrees C, giving 2.8 molecules of ATP hydrolyzed for every vinblastine molecule transported in a particular direction. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | The vinblastine-stimulated ATPase activity of P-glycoprotein has a turnover number of 3.5 s-1 at 37 degrees C, giving 2.8 molecules of ATP hydrolyzed for every vinblastine molecule transported in a particular direction. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |