Title : Physiological and morphological effects of genetic alterations leading to a reduced synthesis of UDP-glucose in Saccharomyces cerevisiae.

Pub. Date : 1997 Aug 1

PMID : 9252577






3 Functional Relationships(s)
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1 A further reduction of flux towards UDP-Glc was achieved by deletion of the two phosphoglucomutase genes in the ugp1 conditional strain. Uridine Diphosphate Glucose UTP glucose-1-phosphate uridylyltransferase Saccharomyces cerevisiae S288C
2 Taken altogether, these results indicate that a few percent of enzymatic activities leading to the formation of UDP-Glc appears sufficient to provide the UDP-Glc demands required for cell viability, and that the loss of function of UGP1 is lethal mainly because of the inability of yeast cells to properly form the cell wall. Uridine Diphosphate Glucose UTP glucose-1-phosphate uridylyltransferase Saccharomyces cerevisiae S288C
3 Taken altogether, these results indicate that a few percent of enzymatic activities leading to the formation of UDP-Glc appears sufficient to provide the UDP-Glc demands required for cell viability, and that the loss of function of UGP1 is lethal mainly because of the inability of yeast cells to properly form the cell wall. Uridine Diphosphate Glucose UTP glucose-1-phosphate uridylyltransferase Saccharomyces cerevisiae S288C