Pub. Date : 1997 Aug 15
PMID : 9252414
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation. | Phosphatidylcholines | phosphatidylinositol/phosphatidylcholine transfer protein SEC14 | Saccharomyces cerevisiae S288C |
| 2 | In yeast, mutations in the CDP-choline pathway for phosphatidylcholine biosynthesis permit the cell to grow even when the SEC14 gene is completely deleted (Cleves, A., McGee, T., Whitters, E., Champion, K., Aitken, J., Dowhan, W., Goebl, M., and Bankaitis, V. (1991) Cell 64, 789-800). | Phosphatidylcholines | phosphatidylinositol/phosphatidylcholine transfer protein SEC14 | Saccharomyces cerevisiae S288C |
| 3 | We show that the increased choline excretion in sec14(ts) cki1 cells is due to increased turnover of phosphatidylcholine via a mechanism consistent with phospholipase D-mediated turnover. | Phosphatidylcholines | phosphatidylinositol/phosphatidylcholine transfer protein SEC14 | Saccharomyces cerevisiae S288C |
| 4 | We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated. | Phosphatidylcholines | phosphatidylinositol/phosphatidylcholine transfer protein SEC14 | Saccharomyces cerevisiae S288C |
| 5 | We propose that the elevated rate of phosphatidylcholine turnover in sec14(ts) cki1 cells provides the metabolic condition that permits the secretory pathway to function when Sec14p is inactivated. | Phosphatidylcholines | phosphatidylinositol/phosphatidylcholine transfer protein SEC14 | Saccharomyces cerevisiae S288C |
| 6 | As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-). | Phosphatidylcholines | phosphatidylinositol/phosphatidylcholine transfer protein SEC14 | Saccharomyces cerevisiae S288C |