Title : Mutations in the IDH2 gene encoding the catalytic subunit of the yeast NAD+-dependent isocitrate dehydrogenase can be suppressed by mutations in the CIT1 gene encoding citrate synthase and other genes of oxidative metabolism.

Pub. Date : 1997 Aug 1

PMID : 9244391






1 Functional Relationships(s)
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1 Citrate and isocitrate concentrations were also elevated in the idh2 mutants, but probably not to toxic levels. isocitric acid isocitrate dehydrogenase (NAD(+)) IDH2 Saccharomyces cerevisiae S288C