Title : Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

Pub. Date : 1997 Jun

PMID : 9241661






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Cyclophosphamide and ifosfamide are alkylating agent prodrugs that require activation by cytochrome P450 (CYP) to manifest their cancer chemotherapeutic activity. Cyclophosphamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Cyclophosphamide and ifosfamide are alkylating agent prodrugs that require activation by cytochrome P450 (CYP) to manifest their cancer chemotherapeutic activity. Cyclophosphamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens