Title : The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents.

Pub. Date : 1997 Aug

PMID : 9234735






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In light of the JNK/SAPK-dependent induction of c-jun and c-fos transcription, and the Jun/Fos-induced transcription of xenobiotic-metabolizing enzymes, these data provide a potential critical role of JNK/SAPK and p38 in the induction of a cellular defense program against cytotoxic xenobiotics such as MMS. Methyl Methanesulfonate mitogen-activated protein kinase 14 Homo sapiens