Title : Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta.

Pub. Date : 1997 Jul 3

PMID : 9233784






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Most human colon and gastric cancers with microsatellite instability (MI) have frameshift mutations in polynucleotide repeats within the RII coding region; these mutations truncate the receptor protein and disable the serine/threonine kinase to produce TGF-beta resistance. Polynucleotides transforming growth factor beta 1 Homo sapiens