Title : Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites.

Pub. Date : 1997 Jul

PMID : 9223567






1 Functional Relationships(s)
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1 The IC50 value of DTZ against CYP3A4-mediated testosterone 6beta-hydroxylation (substrate concentration, 50 microM) was 120 microM. testosterone 6beta cytochrome P450 family 3 subfamily A member 4 Homo sapiens