Title : Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites.

Pub. Date : 1997 Jul

PMID : 9223567






1 Functional Relationships(s)
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1 The CYP3A4 inhibitors ketoconazole and troleandomycin decreased microsomal DTZ oxidation, but inhibitors or substrates of CYP2C, CYP2D and CYP2E1 produced no inhibition. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens