Pub. Date : 1997 Jul 8
PMID : 9207086
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of PARP-/- mice either by the alkylating agent N-methyl-N-nitrosourea (MNU) or by gamma-irradiation revealed an extreme sensitivity and a high genomic instability to both agents. | Methylnitrosourea | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | Treatment of PARP-/- mice either by the alkylating agent N-methyl-N-nitrosourea (MNU) or by gamma-irradiation revealed an extreme sensitivity and a high genomic instability to both agents. | Methylnitrosourea | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | Mice-derived PARP-/- cells displayed a high sensitivity to MNU exposure: a G2/M arrest in mouse embryonic fibroblasts and a rapid apoptotic response and a p53 accumulation were observed in splenocytes. | Methylnitrosourea | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |