Title : Use of the comet assay to investigate possible interactions of nitric oxide and reactive oxygen species in the induction of DNA damage and inhibition of function in an insulin-secreting cell line.

Pub. Date : 1997 Apr 29

PMID : 9202724






2 Functional Relationships(s)
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1 In the present study, we have compared SIN-1, which generates nitric oxide, superoxide anion and hydrogen peroxide, with two other nitric oxide donors, S-nitrosoglutathione (GSNO) and the tetra-iron-sulphur cluster nitrosyl, Roussin"s black salt (RBS). Hydrogen Peroxide MAPK associated protein 1 Homo sapiens
2 In addition, H2O2 may be formed in the presence of SIN-1 and may form hydroxyl radical in the presence of a transition metal, such as Fe2+. Hydrogen Peroxide MAPK associated protein 1 Homo sapiens