Pub. Date : 1997 Jun 9
PMID : 9202156
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | cAMP stimulates protein kinase B in a Wortmannin-insensitive manner. | Cyclic AMP | protein tyrosine kinase 2 beta | Homo sapiens |
| 2 | Here, we show that agents which raise intracellular cAMP can also stimulate PKB. | Cyclic AMP | protein tyrosine kinase 2 beta | Homo sapiens |
| 3 | In addition, the activation pathway of PKB by cAMP seems to be linked to that of growth factors, albeit downstream of PI3-kinase. | Cyclic AMP | protein tyrosine kinase 2 beta | Homo sapiens |
| 4 | Evidence for this is that a constitutive active PKB, T308D, S473D, containing activating mutations in the serine and threonine residues which are phosphorylated subsequent to PI3-kinase activation, cannot be further stimulated by cAMP elevations. | Cyclic AMP | protein tyrosine kinase 2 beta | Homo sapiens |
| 5 | Hence, these data suggest that, in addition to growth factors, cAMP can also lead to activation of PKB. | Cyclic AMP | protein tyrosine kinase 2 beta | Homo sapiens |
| 6 | This cAMP stimulatory action appears to require phosphorylation of T308 and S473, and hence would indicate that cAMP modulates the phosphorylation event of these PKB regulatory sites. | Cyclic AMP | protein tyrosine kinase 2 beta | Homo sapiens |
| 7 | This cAMP stimulatory action appears to require phosphorylation of T308 and S473, and hence would indicate that cAMP modulates the phosphorylation event of these PKB regulatory sites. | Cyclic AMP | protein tyrosine kinase 2 beta | Homo sapiens |